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Anales Del Sistema Sanitario de Navarra 2012Endobronchial lipoma is an extremely rare benign tumour, which usually causes symptoms related with bronchial obstruction. Chest computed tomography shows a homogeneous...
Endobronchial lipoma is an extremely rare benign tumour, which usually causes symptoms related with bronchial obstruction. Chest computed tomography shows a homogeneous mass with fat density and without contrast enhancement. Definitive diagnosis is made with bronchoscopy and biopsy of the tumour. The treatment of choice is endoscopic resection. We present a case of an endobronchial lipoma in a 74 year-old patient, with a medical history of papilar thyroid gland carcinoma, resected endoscopically.
Topics: Aged; Bronchial Neoplasms; Bronchoscopy; Female; Humans; Lipoma; Radiography
PubMed: 23296241
DOI: 10.23938/ASSN.0111 -
Revista Portuguesa de Pneumologia 2009The current state of molecular knowledge on lung cancer demands a histological classification which goes beyond small-cell and non-small-cell carcinoma to provide... (Comparative Study)
Comparative Study Review
The current state of molecular knowledge on lung cancer demands a histological classification which goes beyond small-cell and non-small-cell carcinoma to provide support for tailored therapy in aiding in understanding of the drugs currently available. As diagnosis and follow-up in the vast majority of lung cancer cases is based on biopsies and cytology samples, Immunohistochemical Bronchial Pulmonary Carcinoma Classification (IBPCC) is necessary to reveal the raft of characteristics available. This provides morphological support for the WHO's 1999/2004 classification, in addition to an understanding of carcinogenesis. The immunohistochemical panel clarifies the main morphology and cytology characteristics to maintain the leading histological types as squamous cell carcinoma (high weight molecular cytokeratins/HWMC), adenosquamous carcinoma (CK7, TTF1, HWMA), neuroendocrine carcinoma (Chrg, Syn, CD56, TTF1, Ki67), adenocarcinoma (CK7, CK20, TTF1) and bring the polymorphic and pleomorphic carcinomas under a single banner of pleomorphic carcinoma (Ck7, TTF1, HWMC, VMT, Desmin, Actin) which shelters large cell carcinomas and sarcomatoid carcinomas. Lung cancer chemotherapy will still be based on platinum and gemcitabine for the near future and the IBPCC is a simple and efficient tool for streamlining the registration of lung cancer histological characteristics in biopsies and other reduced samples to support clinical evidence and trials.
Topics: Adenocarcinoma; Biopsy; Bronchial Neoplasms; Immunohistochemistry; Lung Neoplasms; World Health Organization
PubMed: 19859629
DOI: No ID Found -
Thorax Jul 1997
Topics: Bronchial Neoplasms; Equipment Design; Humans; Stents; Tracheal Neoplasms
PubMed: 9246144
DOI: No ID Found -
British Medical Journal Sep 1971
Topics: Adult; Bronchial Neoplasms; Bronchography; Humans; Mucocele; Prognosis; Tomography
PubMed: 5097962
DOI: No ID Found -
Annals of Surgery Jun 1968
Topics: Adenoma; Bronchial Neoplasms; Carcinoma, Adenoid Cystic; Female; Humans; Male; Methods; Myoepithelioma; Neoplasm Metastasis
PubMed: 4297365
DOI: 10.1097/00000658-196806000-00008 -
Chirurgia (Bucharest, Romania : 1990) Oct 2022Triple sleeve bronchial resection with bronchial anastomosis is a complex surgical procedure, more difficult than the standard techniques of bronchial resection and...
Triple sleeve bronchial resection with bronchial anastomosis is a complex surgical procedure, more difficult than the standard techniques of bronchial resection and anastomosis, commonly used to treat benign or low-grade malignant neoplasms (such as carcinoid tumours) that are located on the central bronchial axis (primary and lobar bronchi). When performed carefully by a highly trained surgeon, bronchial sleeve resection and reconstruction is a safe and effective surgical procedure. The complete preservation of the lung parenchyma is the main advantage of this surgical technique, along with a radical bronchial tumour resection. Sparing pulmonary function is crucial for both young (to maintain an optimal effort capacity) and elderly patients as well as those with impaired cardiopulmonary function (they may not tolerate lobectomy or pneumonectomy).
Topics: Humans; Aged; Pneumonectomy; Treatment Outcome; Bronchi; Bronchial Neoplasms; Lung; Lung Neoplasms
PubMed: 36318692
DOI: 10.21614/chirurgia.2730 -
Thorax Jan 1969Some features of 22 cases of carcinoid tumour are described. The histology of the tumour was the criterion for inclusion in the series. The histology was reviewed by an...
Some features of 22 cases of carcinoid tumour are described. The histology of the tumour was the criterion for inclusion in the series. The histology was reviewed by an observer unfamiliar with the clinical features. Six patients, each with an entirely endobronchial tumour of typical histology treated satisfactorily by surgery, are excluded from further consideration; the remaining 16 are considered for factors which may be significant in assessing the long-term prognosis, in addition to a histological assessment. The experience in this series is compared with a number of considerably larger series from the literature. The conclusion is reached that no single feature, histological or clinical, can be a basis for reaching a reliable prognosis. Lobectomy is regarded as the operation of choice in treatment.
Topics: Adenoma; Adolescent; Adult; Bronchial Neoplasms; Bronchography; Carcinoid Tumor; Female; Humans; Lung; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local
PubMed: 5763510
DOI: 10.1136/thx.24.1.43 -
Pediatric Pulmonology Nov 2000Persistent atelectasis and recurrent pneumonia in the same location should raise suspicion of congenital anomalies or obstructing lesions of the bronchus leading to the... (Review)
Review
Persistent atelectasis and recurrent pneumonia in the same location should raise suspicion of congenital anomalies or obstructing lesions of the bronchus leading to the affected area. We present an 8-year-old black female with a history of recurrent fever, cough, atelectasis of the right middle and lower lobes, and weight loss for several months. Flexible bronchoscopy revealed a polypoid mass obstructing the bronchus intermedius. Biopsy of the neoplasm demonstrated a granular cell tumor (GCT). The patient had a lobectomy of the right lower and middle lobes. She had no recurrence of the tumor after several years of follow-up.
Topics: Biopsy; Bronchi; Bronchial Neoplasms; Bronchoscopy; Child; Female; Follow-Up Studies; Granular Cell Tumor; Humans; Pneumonia; Pulmonary Atelectasis
PubMed: 11064434
DOI: 10.1002/1099-0496(200011)30:5<425::aid-ppul9>3.0.co;2-1 -
Therapeutic Advances in Respiratory... 2023Bronchial lipoma is a rare benign tumor of the lung, which is often misdiagnosed due to concomitant pulmonary diseases. In addition, the coexistence of endobronchial... (Review)
Review
Bronchial lipoma is a rare benign tumor of the lung, which is often misdiagnosed due to concomitant pulmonary diseases. In addition, the coexistence of endobronchial lipoma and lung cancer is extremely unusual. To date, no related computed tomography (CT) images have been reported. The patient was a 53-year-old man, who was admitted to our hospital with cough, yellow phlegm, and fever for 1 week. The CT image showed an irregular mass in the medial segment of the right middle lobe (B) with surrounding ground glass opacity, and another solid nodule in the right lower lobe (B). Unfortunately, after 2 weeks of anti-inflammatory treatment, the bronchial invasion of the B nodule did not decrease significantly, so further bronchoscopy was carried out and tumor resection was performed using endoscopic mucosal resection with a ligation device (EMR-L). During the follow-up 4 months, it was found that the B nodule was marked enlargement and then removed. The lesions of the B and B were confirmed as endobronchial lipoma and squamous cell carcinoma (T1aN0M0) by histopathology and immunohistochemical staining, respectively, and no postoperative radiotherapy or chemotherapy was performed. Regrettably, after 29 months of follow-up, we observed recurrence and slow enlargement of the lipoma in its original location, progressive emphysema in both lungs, and solitary chest wall metastasis from the B squamous cell carcinoma that had been resected. Therefore, endobronchial endoscopy resection should be carefully selected for larger endobronchial lipoma. If it is accompanied by early squamous cell carcinoma (T1aN0M0), we still recommend active postoperative chemoradiotherapy.
Topics: Male; Humans; Middle Aged; Bronchial Neoplasms; Endoscopy; Bronchoscopy; Lipoma; Carcinoma, Squamous Cell
PubMed: 37886829
DOI: 10.1177/17534666231208575 -
The Journal of Pathology. Clinical... May 2021We collected 26 cases of bronchiolar adenoma (BA) and its variants, and performed a comprehensive characterization using a combination of morphological,...
We collected 26 cases of bronchiolar adenoma (BA) and its variants, and performed a comprehensive characterization using a combination of morphological, immunohistochemical, and genetic assessments. Of these 26, 13 were classic bilayered cases, including 10 proximal and 3 distal-type BAs. Of note, we also identified 13 cases that lacked a continuous basal cell layer. In five cases, the adenomas were partially classic bilayered, leaving a single layer of columnar or cuboidal epithelial cells in some areas of the lesion (BA with monolayered cell lesions). In the other eight cases, the glandular or papillary structures were entirely composed of monolayered columnar or cuboidal epithelial cells, which were morphologically identical to the luminal epithelial cells of classic BA (monolayered BA-like lesions). Immunohistochemical analysis revealed thyroid transcription factor 1 expression by ciliated columnar epithelial cells, basal cells, and nonciliated columnar and cuboidal epithelial cells. Basal cells also expressed p40 and p63. Twenty-five cases underwent next-generation sequencing using a 422-cancer-gene panel (GeneseeqPrime). Oncogenic driver mutations were detected in 23 cases, including 13 (52%) with EGFR mutations, 4 (16%) with KRAS G12D/V mutations, 3 (12%) with BRAF V600E mutations, 2 (8%) with ERBB2 exon 20 insertions, and 1 (4%) with a RET fusion. EGFR exon 20 insertions were present in 100% of BAs with monolayered cell lesions, 37.5% of monolayered BA-like lesions, and 8% of classic BA (Fisher's exact test, p = 0.002, false discovery rate = 0.014). Collectively, our study revealed a gradual morphological transition between BA and its variants. The genetic composition of BAs with monolayered structures differed significantly from those of classic BAs or lung adenocarcinoma.
Topics: Adenoma; Adult; Aged; Biomarkers, Tumor; Biopsy; Bronchial Neoplasms; DNA Mutational Analysis; Diagnosis, Differential; Female; Gene Fusion; High-Throughput Nucleotide Sequencing; Humans; Immunohistochemistry; In Situ Hybridization; Male; Middle Aged; Molecular Diagnostic Techniques; Mutation; Predictive Value of Tests; Retrospective Studies
PubMed: 33400370
DOI: 10.1002/cjp2.197